ea0037gp.15.06 | Diabetes and obesity – basic | ECE2015
Gormley Noella
, Flatt Peter
, McKillop Aine
GPR120 is a rhodopsin-like GPCR that has a high affinity for long-chain saturated fatty acids 1418 carbons and unsaturated fatty acids 1622 carbons. The beneficial effects of GPR120 on β-cell function and glucose homeostasis have recently been reported however its role in glucagon secretion is unknown. GPR120 and glucagon expression were examined by double immunohistochemical studies using a glucagon secreting cell line (α-TC1.9) and pancreatic tissue fro...